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Large-cell lung carcinoma with rhabdoid phenotype : ウィキペディア英語版 | Large-cell lung carcinoma with rhabdoid phenotype
Large cell lung carcinoma with rhabdoid phenotype (LCLC-RP) is a rare histological form of lung cancer, currently classified as a variant of large cell lung carcinoma (LCLC). In order for a LCLC to be subclassified as the rhabdoid phenotype variant, at least 10% of the malignant tumor cells must contain distinctive structures composed of tangled intermediate filaments that displace the cell nucleus outward toward the cell membrane.〔 The whorled eosinophilic inclusions in LCLC-RP cells give it a microscopic resemblance to malignant cells found in rhabdomyosarcoma (RMS), a rare neoplasm arising from transformed skeletal muscle. Despite their microscopic similarities, LCLC-RP is not associated with rhabdomyosarcoma. Although rhabdoid variants of LCLC are sometimes referred to as "rhabdoid carcinomas", this particular term should be reserved for examples of "pure" rhabdoid neoplasms (i.e. those that do not contain cells containing other histological variants) ==History== Although Colby and colleagues were the first to report a primary lung cancer with a rhabdoid phenotype in a paper published in 1995, cells with these characteristic features had been previously noted in 1978, when they were noted to occur in a rare and extremely aggressive form of kidney cancer that appears almost exclusively in young children called "Wilms tumor".〔 LCLC-RP were first recognized as a distinct entity under the 3rd (published in 1999) revision of the World Health Organization (WHO) lung tumor histological typing scheme. Its placement in the classification schema went unchanged during the 2004 revision.〔
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